Specific marrow ablation before marrow transplantation using an aminophosphonic acid conjugate 166Ho-EDTMP

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Specific marrow ablation before marrow transplantation using an aminophosphonic acid conjugate 166Ho-EDTMP.

166Holmium ethylenediaminetetramethylene phosphonic acid (166Ho-EDTMP) is a short-lived beta-emitting radionuclide complexed to an aminophosphonate ligand that we have investigated in a canine model as a potential agent for specific marrow ablation before marrow transplantation. After intravenous injections, 166Ho-EDTMP distributed principally to bone and after 24 hours the concentrations of 16...

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ژورنال

عنوان ژورنال: Blood

سال: 1992

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v80.6.1608.1608